Background: Smoking is known as the major cause of chronic obstructive pulmonary disease (COPD). In COPD, most of pulmonary function tests (PFTs) specially those indicating the diameter of airways are reduced. There are reports that bronchodilator drugs have no or a very little effect on PFT of COPD patients. Therefore, in this study PFTs of smokers were compared with those of nonsmokers, and the effect of bronchodilator inhaler (salbutamol) on PFTs of smokers were also examined.Materials & Methods: Pulmonary function tests were measured in 97 male smokers (height 171.71±6.68 cm, age 36.49±13.06 years old) and compared with 95 male nonsmokers (height 171.79±8.81 cm, age 35.56±12.83 years old). The subjects underwent measurement of spirometric flow and volume. The following variables were measured: forced vital capacity (FVC), forced expiratory volume in one second (FEV1), maximal mid-expiratory flow (MMEF), peak expiratory flow (PEF), maximal expiratory flow at 75%, 50%, and 25% of the FVC (MEF75, MEF50, and MEF25 respectively). In addition, pulmonary function tests of 33 male smokers (height 172.79±11.94cm, age 38.30±6.65 years old) before and 10 minutes after administration of 200 A?g salbutamol inhaler were measured.Results: The results showed that most values of PFTs in smokers were significantly lower than those of non-smokers (p<0.001 for FVC, FEV1, PEF, MEF75, p<0.01 for MMEF, and p<0.02 for MEF50). However, there were not significant differences in MEF25 of smokers and non-smokers. There were significant correlations between the smoking duration and FEV1, PEF, MEF75, and MEF50 (p<0.05 to p<0.01), but correlations between smoking quantity and values of PFTs were not significant. The results also showed that all values of PFTs were significantly increased after salbutamol administration (p<0.05 to p<0.01). The enhancement in PEF, MEF75, and MEF50 was around 12% and that of MEF25 was 17%.Conclusion: The profound effect of smoking on PFT showed that smoking leads to constriction of large and medium sized airways which is mostly due to duration not to quantity of smoking. The airway constriction in smokers was reversible which, was mostly seen for medium sized airways.